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The only significant predator of the giraffe are lions. Of course they will try to take on other forms of prey first unless they are extremely hungry. They will look for the young and for the weak giraffes too. Even though they can easily outrun these animals there is more to the story than just that. Giraffe Skin Disease is a skin disorder that causes crusty lesions on the legs of Maasai giraffes. Affected skin appears itchy, making the giraffe frequently scratch by rubbing against branches of smaller bushes. Some affected giraffe are reluctant to use their legs; they stand at one place for long periods and show signs of lameness, possibly making them more vulnerable to predation or poaching.